McArthur, Mark

McArthur, Mark D.V.M. D.A.C.V.P.

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Research Interests

Pathology of transgenic and gene targeted mice, pathology of rodent models of carcinogenesis, and the role of acyl-CoA binding protein in carcinogenesis

Current Research

Research in Dr. McArthur’s laboratory focuses on the involvement of lipid metabolism in carcinogenesis. This includes studies of ACBP (acyl Co-A Binding Protein) in carcinogenesis and the transitional cell carcinoma that develops in a transgenic mouse that over-expresses COX-2 (cyclo-oxygenase 2) in the urothelium under the bovine keratin 5 promoter.

Due to my extensive training and experience in pathology, especially the characterization of genetically engineered mice, I am involved in numerous collaborative projects with multiple members of the Department of Carcinogenesis faculty. These collaborations allow significant contributions to the understanding of rodent models of cell cycle regulation, carcinogenesis, and cancer therapeutics. This has recently been formalized with my appointment as co-Director of the Cancer Center Support Grant – Mutant Mouse Pathology Service. Dr. Donna Kusewitt, recently recruited to the Department of Carcinogenesis, serves as the Director of the service, a fee for service pathology service, for a number of investigators.

Selected Publications

  1. Wang A, Arantes S, Conti C, McArthur M, Aldaz CM, Macleod MC. Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells, Mol Carcinog, 46 (6), 476-87, 2007
  2. Baze WB, Steinbach TJ, Fleetwood ML, Blanchard TW, Barnhart KF, McArthur MJ. Karyomegaly and intranuclear inclusions in the renal tubules of sentinel ICR mice (mus musculus), Comp Med, 56 (5), 435-8, 2006
  3. Paulson QX, McArthur MJ, Johnson DG. E2F3a stimulates proliferation, p53-independent apoptosis and carcinogenesis in a transgenic mouse model, Cell Cycle, 5 (2), 184-90, 2006
  4. Pusapati RV, Rounbehler RJ, Hong S, Powers JT, Yan M, Kiguchi K, McArthur MJ, Wong PK, Johnson DG. ATM promotes apoptosis and suppresses tumorigenesis in response to Myc, Proc Natl Acad Sci U S A, 103 (5), 1446-51, 2006
  5. Cantrell JT, McArthur MJ, Pishko MV. Transdermal extraction of interstitial fluid by low-frequency ultrasound quantified with 3H2O as a tracer molecule, J Pharm Sci, 89 (9), 1170-9, 2000
  6. Swaggerty CL, Frolov AA, McArthur MJ, Cox VW, Tong S, Compans RW, Ball JM. The envelope glycoprotein of simian immunodeficiency virus contains an enterotoxin domain, Virology, 277 (2), 250-61, 2000
  7. McArthur MJ, Atshaves BP, Frolov A, Foxworth WD, Kier AB, Schroeder F. Cellular uptake and intracellular trafficking of long chain fatty acids, J Lipid Res, 40 (8), 1371-83, 1999
  8. Donehower LA, Harvey M, Vogel H, McArthur MJ, Montgomery CA, Jr., Park SH, Thompson T, Ford RJ, Bradley A. Effects of genetic background on tumorigenesis in p53-deficient mice, Mol Carcinog, 14 (1), 16-22, 1995

Contact Information


Mailing Address: Department of Veterinary Sciences, Unit 119, 650 Cool Water Drive, Bastrop, Texas 78602
Physical Address: Phone: (512) 332-5399