Global Gene Expression Group

SAGE Projects - Aldaz Laboratory

Human Breast Cancer

• Breast Cancer Molecular Signatures as Determined by SAGE: Correlation with Lymph Node Status
• GATA3 protein as a MUC1 transcriptional regulator in breast cancer cells
• Gene Expression Signature of Estrogen Receptor α Status in Breast Cancer
• Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression
• Effects of Estrogen on Global Gene Expression: Identification of Novel Targets of Estrogen Action

Mouse Models of Cancer

• Transcriptomic signature of the chemopreventive Bexarotene (Rexinoid LGD1069) on mammary gland from three transgenic mouse mammary cancer models
• Identification of Novel Amplification Gene Targets in Mouse and Human Breast Cancer at a Syntenic Cluster Mapping to Mouse ch8A1 and Human ch13q34
• SAGE Profiling of UV-Induced Mouse Skin Squamous Cell Carcinomas, Comparison with Acute UV Irradiation Effects.
• From Mice To Humans: Identification Of Commonly Deregulated Genes In Mammary Cancer via Comparative SAGE Studies.
• Serial Analysis of Gene Expression in Normal p53 Null Mammary Epithelium.
• Effects of Ultraviolet Light Irradiation in E2F1 Null Mouse Skin. Unpublished data. Access data with password.

General

• Overdispersed Logistic Regression for SAGE: Modelling Multiple Groups and Covariates.
• Differential expression in SAGE: accounting for normal between-library variation.
• Review: Serial Analysis of Gene Expression (SAGE) in Cancer Research.

Other

• SAGE Links:  SAGE Genie   SAGEmap   SAGEnet   Genzyme  

RAGE Projects - MacLeod Laboratory

Human

• Response of human mammary epithelial cells to DNA damage induced by BPDE: involvement of novel regulatory pathways

Mouse

• Effects of overexpression of human E2F1 on gene expression in murine keratinocytes.

Other

• RAGE Links:  Capital Genomix, Inc.  

Tools

• Global gene expression informatics tools at Science Park