• Review Articles

• Publications Before 2001

2008

Bhatia, B., Multani, A.S., Patrawala, L., Chen, X., Calhoun-Davis, T., Zhou, J., Schroeder, L., Schneider-Broussard, R., Shen, J., Pathak, S., Chang, S., and Tang, D.G.  Evidence that senescent human prostate epithelial cells enhance tumorigenicity: Cell fusion as a potential mechanism and inhibition by p16INK4a and hTERT.  Int. J. Cancer 122, 1483-1495, 2008.

Patrawala L, and Tang DG. CD44 as a functional cancer stem cell marker and therapeutic target. In: Progress in Gene Therapy. (Bertolotti R &  Ozawa K, ed). World Scientific Publishers, pp317-334, 2008.

Li, H.W., Chen, X., Calhoun-Davis, T., Claypool, K., and Tang, D.G.  PC3 human prostate carcinoma cell holoclones contain self-renewing tumor-initiating cells.  Cancer Res. 68: 1820-1825, 2008.

Tang DG. Stem-like cancer cells. In: Cancer Encyclopedia. (Schwab M, ed). 2008, in press.

Qin JC, and Tang DG. Cancer stem cells: A definition. In: Stem Cells and Cancer (Dittmar T & Zanker KS, ed). Nova Science Publishers, 2008, in press.

Li HW, Jiang M, Honorio S, Patrawala L, Jeter C, Calhoun-Davis T, Hayward SW, and Tang DG. Methodologies in assaying prostate cancer stem cells. Methods in Mol. Biol. (Yu JS, ed), Humana Press. 2008, in press.

Honorio S, Li H, and Tang DG. Prostate cancer stem/progenitor cells. In: Stem Cells and Cancer. (Bagley RG & Teicher BA, ed). Humana Press. 2008, in press.

2007

Tang, D.G., Patrawala L, Calhoun T, Bhatia B, Schneider-Broussard R, Choy, G., and Jeter, C.  Prostate cancer stem/progenitor cells: Identification, characterization, and implications.  Mol. Carcinogenesis 46, 1-14, 2007.

Patrawala, L., Calhoun-Davis, T., Schneider-Broussard, R., and Tang, D.G.  Hierarchical organization of prostate cancer cells in xenograft tumors: The CD44+a2b1+ cell population is enriched in tumor-initiating cells.  Cancer Res. 67, 6796-6805, 2007.

Chandra, D., Choy, G., and Tang, D.G.  Cytosolic accumulation of HSP60 during apoptosis with or without apparent mitochondrial release – evidence that its pro-apoptotic or pro-survival functions involve differential interactions with caspase-3.  J Biol Chem. 282, 31289-31301, 2007.

Tang, D.G., Bhatia, B., Tang S., and Schneider-Broussard, R. 15-Lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size). Prostaglandins & other Lipid Mediat. 82: 135-146, 2007.

2006

Chandra, D., Bratton, S.B., Person, M.D., Tian, Y., Martin, A., Ayers, M., Fearnhead, H.O., Gandhi, V., and Tang, D.G. Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting formation of Apaf-1 apoptosome. Cell 125, 1333-1346, 2006.

Patrawala L, Calhoun T, Schneider-Broussard R, Li H, Bhatia B, Tang S, Reilly JG, Chandra D, Zhou J, Claypool K, Coghlan L, and Tang DG.  Highly purified CD44+ prostate cancer cells from xenograft human tumors are enriched in tumorigenic and metastatic progenitor cells.  Oncogene25, 1696-1708, 2006.

2005

Liu, J-W., Chandra, D., Rudd, M.D., Butler, A.P., Pallotta, V., Brown, D., Coffer, P.J., and Tang, D.G.  Induction of pro-survival molecules by apoptotic stimuli: Involvement of FOXO3a and ROS.  Oncogene 24, 2020-2031, 2005.

Bhatia, B., Tang, S., Yang, P., Doll, A., Aumüeller, G., Newman, R.A., and Tang, D.G.  Cell-autonomous induction of functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) contributes to replicative senescence of human prostate progenitor cells.  Oncogene 24, 3583-3595, 2005.

Chandra, D., Choy, G,. Daniel, P.T., and Tang, D.G.  Bax-dependent regulation of Bak by VDAC-2.  J. Biol. Chem. 280, 19051-19061, 2005.

Patrawala,  L., Calhoun, T., Schneider-Broussard, R., Zhou, J., Claypool, K., and Tang, D.G.  Side population (SP) is enriched in tumorigenic, stem-like cancer cells whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic.  Cancer Res. 65, 6207-6219, 2005.

2004

Chandra, D., Choy, G., Deng, X., Bhatia, B., and Tang, D.G. Active caspase-8 on the outer mitochondrial membrane cleaves BAP31 and caspase-3 and mediates mitochondria – ER crosstalk in etoposide-induced apoptosis. Mol. Cell. Biol. 24: 6592-6607, 2004.

Tang, S-H., Bhatia, B., Zhou, J-J., Maldonado, C.J., Chandra, D., Kim, E., Fischer, S., Butler, A.F., Friedman, S.L., and Tang, D.G. Evidence that Sp1 positively and Sp3 negatively regulate and androgen does not directly regulate the functional tumor suppressor 15-lipoxygenase 2 (15-LOX2) gene expression in normal prostate epithelial cells. Oncogene 23: 6942-6953, 2004.

2003

Liu, J-W., Shen J-J., Tanzillo-Swarts, A, Bhatia, B., Maldonado, C., Person, M.D., Lau, S., and Tang, D.G.Annexin II expression is reduced or lost in prostate cancer cells and its re-expression inhibits prostate cancer cell migration. Oncogene 22: 1475-1485, 2003.

Chandra, D., and Tang, D.G. Mitochondrially-localized active caspase-9 and caspase-3 result mostly from translocation from the cytosol and partly from caspase-mediated activation in the organelle. Lack of evidence for Apaf-1-mediated caspase-9 activation in the mitochondria. J. Biol. Chem. 278: 17408-17420, 2003.

Bhatia, B., Maldonado, C., Tang, S-H., Chandra, D., Klein, R.D., Chopra, D., Shappell, S., Yang, P.,Newman,  R.A., and Tang, D.G. Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants. J. Biol. Chem. 278: 25091-25100, 2003.

2002

Tang, S., Bhatia, B., Maldonado, C., Yang, P., Newman, R.A., Liu, J., Chandra, D., Traag, J., Klein, R.D., Fischer, S.M., Chopra, D., Shen, J., Zhau, H., Chung, L.W.K., andTang, D.G. Evidence that arachidonate 15-lipoxygenase 2 is a negative cell-cycle regulator in normal prostate epithelial cells. J. Biol. Chem. 277: 16189-16201, 2002.

Liu, J-W., Chandra, D., Tang, S-H., Chopra, D., and Tang, D.G. Identification and characterization of Bimg, a novel proapoptotic BH3-only splice variant of Bim. Cancer Res. 62: 2976-2981, 2002.

Chandra, D., Liu, J-W., and Tang, D.G. Early mitochondrial activation and cytochrome c up-regulation during apoptosis. J. Biol. Chem. 277: 50842-50854, 2002.

2001

Tang, D.G., Tokumoto, Y.M., Apperly, Lloyd, A.C., and Raff, M.C. Lack of replicative senescence in cultured rat oligodendrocyte precursor cells. Science 291, 868-871, 2001.

Tokumoto YM, Tang DG, Raff MC.  Two molecularly distinct intracellular pathways to oligodendrocyte differentiation: role of a p53 family protein.  EMBO J. 20:5261-5268, 2001.

2000

Tang DG, Tokumoto YM, Raff MC.  Long-term culture of purified postnatal oligodendrocyte precursor cells: Evidence for an intrinsic maturation programme that plays out over months.  J. Cell Biol. 148, 971-984, 2000.

Fernandez P-A, Tang DG, Cheng L, Mudge AW, Prochiantz A, Raff MC.  Evidence that axon-derived neuregulin promotes oligodendrocyte survival in the developing rat optic nerve.  Neuron 28, 81-90, 2000.